6 Ways to Reduce IV Acetaminophen Use in Children's Hospitals

When annual spending on intravenous (IV) acetaminophen increased, Lucile Packard Children’s Hospital Stanford implemented a project to reduce the use of the overprescribed drug.
Download
reduce_iv_acetaminophen_use

When annual spending on intravenous (IV) acetaminophen increased more than $100,000 in one year, Lucile Packard Children’s Hospital Stanford implemented a project to reduce the use of the overprescribed drug.

The effort reinforced the hospital’s goal of managing costs through appropriate drug utilization and disease management. Here's how they found success:

Find clinical champions. Identify key influencers in your facility, or your largest areas of usage, who can help you transition to a more cost-effective and appropriate usage of acetaminophen.

Create order defaults. Default the duration of IV acetaminophen orders to 24 hours. This requires the medical team to evaluate the need for the continuation of the therapy.

Leverage technology. Develop the proper alerts in your ordering platform to aid in converting patients to oral administration. The alert should be easily actionable to improve providers’ acceptance.

Evaluate changes. Monitor key performance indicators for intended changes, and don’t be discouraged if results are not as expected. The solution may require multiple iterations.

Test the changes. Use the plan-do-check-act (PDCA) cycle to evaluate and improve the solutions as needed. Share your successes.

Focus on feedback. Positive feedback will encourage continual engagement and participation in the process changes.

Hand

Contact Us

For more information, contact the Pharmacy Services team.

About Pharmacy Services

Join us in advancing pediatric health care. Partner with CHA to elevate your children's hospital's access to essential pharmacy resources.

Related Content

Why 340B Is Essential for Children's Health

The program makes life-saving drugs more affordable for hospitals that care for our nation’s children.

Oct. 07, 2025

Unlocking Hope with Improved Access to Gene Therapy

The promise of CGTs is tempered by their staggering cost and treatment complexity.

Sep. 23, 2025

How a Health Care Supply Chain Officer Supports Patient Care

Discover insights from a longtime children’s hospital supply chain leader on supporting patient care, community needs, and the health care supply chain.

Sep. 16, 2025