Sepsis Collaborative

Join children’s hospitals across the country to defeat sepsis, a leading cause of death in hospitalized children. Sepsis kills almost 5,000 children annually in the U.S. — more than cancer — and accounts for 16 percent of all pediatric health care spending in the U.S. – around $5 billion. Children’s hospitals are at ground zero of the sepsis crisis: More than 60 percent of pediatric sepsis patients are treated in our hospitals. That is why we are mobilizing in a new collaboration to reduce sepsis deaths and severe sepsis: Improving Pediatric Sepsis Outcomes.

Improving Pediatric Sepsis Outcomes (IPSO) aims to reduce sepsis mortality by 75 percent and reduce hospital-onset severe sepsis by 75 percent. IPSO is addressing all stages of sepsis across the care continuum, including the emergency department, intensive care, general care, hematology/oncology and bone marrow transplant units initially, and NICU, pre-hospital, and ambulatory settings in subsequent phases.

IPSO uses data-driven quality improvements methods and an all-teach-all-learn program model. Hospitals participating in IPSO have access to:

  • Bundles based on the best evidence
  • Measures that are both robust and feasible
  • A data infrastructure that will flex to customize and simplify data submission for each hospital and make it easy to track performance
  • Virtual learning and interaction activities and face-to-face workshops to support and accelerate progress
  • Training, tools and implementation resources to support on-the-ground capacity to do the work

IPSO has been made possible by more than 60 pediatric sepsis experts on the IPSO National Expert Advisory Committee under the leadership of our national co-chairs:

Richard Brilli

Richard Brilli, MD, FAAP, MCCM
Chief Medical Officer, Nationwide Children’s Hospital

Charles MaciasCharles Macias, MD, MPH
Chief Clinical Systems Integration Officer, Texas Children’s Hospital

Matthew Niedner

Matthew Niedner, MD
Director of Quality and Safety, PICU, University of Michigan C.S. Mott Children’s and Von Voigtlander Women’s Hospital   

CHA extends its gratitude and appreciation to these committed clinicians and their hospitals.


Hospitals planning to join the IPSO Collaborative to begin participation with the July cohort of hospitals, must enroll by June 30, 2019.  

All member hospitals are eligible to participate. View enrollment details and resources.



Upcoming Events


Loma Linda sepsis video

Hear from Loma Linda on the impact of fighting sepsis through the IPSO collaborative.

Sepsis Hero

CHA, in collaboration with Sepsis Alliance, celebrates the 2018 Sepsis Heroes.